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Dr Brooke Show #441 Why Your Progesterone to Estrogen Ratio Matters

September 19, 2025
Dr Brooke Show #441 Why Your Progesterone to Estrogen Ratio Matters

Whether you are cycling and have symptoms or are on HRT and having issues, the ratio of these two hormones can be a real indicator of issues like low progesterone, estrogen dominance or estrogen metabolism issues.

You can calculate this ratio from values on your serum testing or urine testing such as the DUTCH test. In this episode, I talk about what this ratio should be, how to calculate it (units matter!), what you can glean from various types of testing (i.e. urine shows you something different than serum, both matter) and what to consider to feel better if your P:E2 ratio is off.

Resources mentioned in the show:

Dr Brooke Show #426 Why Some Women Can’t Tolerate Progesteron

Dr Brooke Show #429 All About PMDD: Premenstrual Dysphoric Disorder

Grab the Midlife Is More Than HRT guide free right here if like me, midlife didn’t feel quite like you expected. And be sure to listen to episodes #438 and #439 which were all about the mess that midlife can be, and my 3G+4R process to tackle it!

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If you are looking for an expert prescriber for HRT during your perimenopause or menopause journey but are at odds with your local provider being a bit behind current best practices or you simply can’t find anyone near you to help, it is MIDI to the rescue! I’ve worked with a number of telehealth services in my search for providers that are up to date on modern menopause medicine, have great customer service and who are licensed in all 50 states and I’m so thrilled to have found my provider with MIDI. If you too need help with getting HRT please use this link bit.ly/drbrookemidi to try MIDI with no membership fees and insurance billing available.

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